Affiliation

• ¹Children’s Hospital of Rabat and Laboratory of Biochemistry and Molecular Biology, Faculty of Medicine and Pharmacy, Rabat, Morocco
• ²Department of Biochemistry and Molecular Biology, University Mohammed V Faculty of Medicine and Pharmacy, Rabat, Morocco
• ³Laboratory of Biochemistry, Hospital Southern, Lyon, France
• ⁴Department of Medicine, Emory University School of Medicine, Atlanta, Georgia USA
• ⁵UFR-Physiology - Pharmacology, Faculty of Sciences, Dhar Mehraz, Fez, Morocco

Corresponding Author

Touzani, Children’s Hospital of Morocco and Laboratory of Biochemistry and Molecular Biology, Faculty of Medicine and Pharmacy, Rabat, Morocco, Tel: 212-37-84398; Fax: 212-7-77-37 01; E-mail: asmaetouzani@hotmail.com

Citation

Touzani, A., et al. Correlation of Leptinemia with Components of Metabolic Syndrome in Moroccan Youths: Influence of Obesity, Blood Pressure, Gender and Stage of Puberty. (2016) J Diab Obes 3(2): 93- 100.

Copy rights

© 2016 Touzani, A. This is an Open access article distributed under the terms of Creative Commons Attribution 4.0 International License.

Keywords

Abstract

Objective: To evaluate correlation of leptinemia with components of Metabolic Syndrome (MetS) in Moroccan youths, and effect of obesity, Blood Pressure (BP), gender and puberty stage on MetS-components.
Study design: Anthropomorphic, metabolic and clinical parameters [Body Mass Index (BMI), Waist Circumference (WC), energy intake, Blood Pressure (BP), Plasma levels of lipids, leptin, Alanine-Amino Transferase (ALT), Apo-B, Uric Acid (UA), glucose, insulin and Insulin Resistance (IR) (Homeostasis-Model-Assessment (HOMA-IR) and Fcβ (intra hepatic-IR)] were determined in 82 obese and 51 non-obese, male and female youths at different stages of puberty.
Results: Obesity was a major but not the only determinant of levels of leptin, BP, triglycerides, insulin, UA and ALT, and HOMA-IR, Fcβ; BMI was correlated with WC, BP and UA. Girls had higher leptin levels than boys, irrespective of obesity. Higher puberty stage was associated with higher values of BP, leptin, and ALT, irrespective of gender. Leptinemia was correlated with MetS-components: BMI, WC, BP, cholesterol, triglycerides, Apo-B, insulin, UA and HOMA-IR in all subjects; 10.8 - 16.2% of obese youths had MetS.
Conclusions: Leptinemia was correlated with several MetS-components. Hyperleptinemia in youths, indicating leptin resistance and IR, could predict development of MetS and cardiovascular disease in adulthood. Early detection of MetS may be helpful in identifying those at risk for T₂DM and CV disease, and preventive measures may be protect them from development of metabolic and cardiac disorders in the future.