Effective of Red Ginseng Extract on Ameliorate Adipogenesis 3t3-L1 by Decreasing P38 and Erk Phosphorylation
Affiliation
Institute of Jinan Red Ginseng, 41 Hongsamhanbang-ro, Jinan-eup, Jinan-gun, Jeonbuk, 55442 Republic of Korea
Corresponding Author
Gi-Beum Kim, Institute of Jinan Red Ginseng, 41 Hongsamhanbang-ro, Jinan-eup, Jinan-gun, Jeonbuk, 55442 Republic of Korea, E-mail: kgb70@jbnu.ac.kr
Kyung-Min Choi, Institute of Jinan Red Ginseng, 41 Hongsamhanbang-ro, Jinan-eup, Jinan-gun, Jeonbuk, 55442 Republic of Korea, E-mail: kyungmc@ijrg.re.kr
Citation
Kim, G.B., et al. Effective of Red Ginseng Extract on Ameliorate Adipogenesis 3T3-L1 by Decreasing P38 and Erk Phosphorylation. (2017) J Diab Obes 4(1): 1- 5.
Copy rights
© 2017 Kim, G.B. This is an Open access article distributed under the terms of Creative Commons Attribution 4.0 International License.
Keywords
Abstract
This study examined the anti-obesity effect and mechanism of action of red ginseng extract (RG) in 3T3-L1 cells. To measure the levels of lipid accumulation, we were observed of expression of genes and proteins, which is associated with adipocyte differentiation in 3T3-L1 cells. Eight days following induction for differentiation with MDI-medium and simultaneously with the tested RG, our study found significantly reduced (p < 0.05) intracellular triacylglycerol accumulations of 3T3-L1 cells by does dependent manner. RG decrease adipogenic markers, C/EBPα, C/EBPβ and PPARγ, which is a key regulator of adipocyte differentiation. In this study showed that C/EBPβ is regulated RG decreased the phosphorylations of p38 mitogen-activated protein kinase (MAPK) and extracellular signal–regulated kinases (ERK). These results suggest that the anti-adipogenic effect of RG in 3T3-L1 pro-adipocyte could be associated with the inhibition of adipogenic transcription factors by regulations with p38 MAPK and ERK phosphorylation.
