Affiliation

Hospital Universitario Severo Ochoa, Department of Medical Oncology, Avenida Orellana s/n Leganés 28911 Madrid, Spain

2 Hospital Universitario Severo Ochoa, Department of General Surgery, Avenida Orellana s/n Leganés 28911 Madrid, Spain †

These authors contributed equally to this work.

Corresponding Author

Ricardo Hitt, Department of Medical Oncology, Hospital Universitario Severo Ochoa, Avenida Orellana s/n Leganés 28911 Madrid, Spain, Tel: +34914818000 (ext. 8305); E-mail: rhitt@telefonica.net & mecharrigonzalez@gmail.com

Citation

Ricardo, H., et al. Fatal Necrotizing Fasciitis after Intramuscular Fulvestrant. (2016) Clin Trials Pathol Case Stud 1(1): 11- 14.

Copy rights

© 2016 Ricardo, H. This is an Open access article distributed under the terms of Creative Commons Attribution 4.0 International License.

Abstract

  Necrotizing fasciitis is a life-threating infection with necrosis of the fascia and the subcutaneous tissues that usually progressed rapidly to a septic shock hence causing high rates of mortality. Risk factors include diabetes, peripheral vascular disease (PVD), immune compromise or recent surgery. Although there are published some cases of necrotizing fasciitis after intramuscular injections, mostly with nonsteroidal anti-inflammatory drugs (NSAIDs), this entity is rare. Hence we report the first case of a 55-year-old woman with metastatic breast cancer presenting to our hospital with a necrotizing fasciitis of the gluteus after intramuscular injection of Fulvestrant (an estrogen receptor antagonist for the treatment of hormone receptor-positive metastatic breast cancer patients).