Affiliation

Institute of Physical Electron and Life Science and Technology, University of Electronic Science and Technology of China, Chengdu 610054, P.R. China

Corresponding Author

Pang Xiao-feng, Institute of Physical Electron and Life Science and Technology, University of Electronic Science and Technology of China, Chengdu 610054, P.R. China. E-mail: pangxf2006@yahoo.com.cn

Citation

Pang Xiao-feng. Investigation of Biological Property of Nanohydroxyapatite Materials. (2017) J Nanotechnol Material Sci 4(2): 75- 81.

Copy rights

© 2017 Pang Xiao-feng. This is an Open access article distributed under the terms of Creative Commons Attribution 4.0 International License.

Keywords

Abstract

  The biological effects of nanohydroxyapatites and its cell toxicity have been studied using the MTT and ALP method, infrared spectrum of absorption and electrophoresis method, respectively. The nanohydroxyapatites are prepared and made by using Sol-gel method, in which the parameters of process and reaction are controlled as: pH > 9, Ca / P = 1.67, sintering temperature of 1100°C and sintering time 2 hours. Studied results show that nanohydroxyapatites can interact with human serum albumin and change its second structure and weight of molecules. We find that the nanohydroxyapatites and complex of nano HAP+ nanoCrO₂ can all restrain the proliferation of MG63 cells, but their toxicities are first degree or minor, the toxicity of the complex is smaller than that of pure nanohydroxyapatites.