Affiliation

• ¹Department of Pathology, The People’s Hospital of Shouguang City, Shanddong Provence, China
• ²Department of Oncology, The People’s Hospital of Shouguang City, Shanddong Provence, China
• ³Department of Health Care, The People’s Hospital of Weifang City, Shanddong Provence, China
• ⁴Department of Pathology, Weifang Medical University, Weifang, Shandong Province, P.R. China

Corresponding Author

Chuanliang Liu, Department of Health Care, The People’s Hospital of Weifang City, Shandong Provence, China. E-mail: chuanliang_liu@163.com

Citation

Liu, C., et al. Let-7a as a Tumor Suppressor Modulates Invasion via Smad2 Signal in Breast Cancer. (2015) Intl J Cancer Oncol 2(2): 1-4.

Copy rights

© 2015 Liu, C. This is an Open access article distributed under the terms of Creative Commons Attribution 4.0 International License.

Keywords

Abstract

  TGF-β elicits tumor promoting effects through its ability to induce EMT which enhances invasiveness and metastasis, the perturbations of TGF-β/Smad signaling are central to carcinogenesis in most of organs. A shift in Smad2/3 phosphorylation from the carboxy terminus to linker sites is a key event determining biological function of TGF-β. Here, we showed that let-7 was associated with breast cancer development and progression by directly targeted Smad2, suggesting a tumor suppressor role of let-7 and its target Smad2 is critical regulators of TGF-β signaling in breast cancer.