Mechanisms of Muscle Weakness Associated with Bone Metastases
Khalid S. Mohammad1, Theresa A. Guise1, Miguel Manzano2,3, Maria Vallet-RegÃ2,3*
Affiliation
- 1Department of Medicine, Division of Endocrinology, Indiana University School of Medicine, IN, USA
- 2Departamento de Química Inorgánica y Bioinorgánica, Facultad de Farmacia, Universidad Complutense de Madrid. Instituto de Investigación Sanitaria Hospital 12 de Octubre i+12, Spain
- 3Networking Research Center on Bioengineering, Biomaterials and Nanomedicine (CIBER-BBN), Madrid, Spain
Corresponding Author
Maria Vallet-Regí, Departamento de Química Inorgánica y Bioinorgánica, Facultad de Farmacia, Universidad Complutense de Madrid. Instituto de Investigación Sanitaria Hospital 12 de Octubre i+12, Spain; Networking Research Center on Bioengineering, Biomaterials and Nanomedicine (CIBER-BBN), Madrid, Spain, Tel: +34913941861/ Fax: +34913941786; E-mail: vallet@ucm.es
Citation
Vallet-Regi, M., et al. Mechanisms of Muscle Weakness Associated with Bone Metastases. (2017) Int J Cancer Oncol 4(2): 1- 5.
Copy rights
© 2017 Vallet-Regi, M. This is an Open access article distributed under the terms of Creative Commons Attribution 4.0 International License.
Keywords
Abstract
Cancer-associated muscle dysfunction represents a deadly clinical problem, for which there is currently no treatment. Normal bone remodeling can be disrupted by tumor cells that metastasize to bone in certain stages of cancer, which results in increased morbidity including muscle weakness. The reason for this muscle weakness may be attributed to a reduction in muscle mass and/or a reduction in muscle function. In fact, it has been demonstrated that in advanced cancers, it is probably caused by a combination of reduced quantity and quality of muscle. This review focuses on the mechanisms that bone metastases promote skeletal muscle weakness in metastatic bone disease.
