Nootropic effects of quince leaf (Cydonia Oblonga Miller.) decoct in mice: A neurobehavioral approach complemented with kinetics and molecular docking studies of encephalic acetylcholinesterase inhibition
Zahraminoosh Siavashhaghighi, Airin Najaf, Lora A Becker
Affiliation
- 1Department of Biology, Faculty of Science, Razi University, Kermanshah, Islamic Republic of Iran
- 2Department of Basic Veterinary Sciences, Laboratory of Molecular and Cellular Biology 1214, Faculty of Veterinary Medicine, Razi University, Kermanshah, Islamic Republic of Iran
- 3Department of Pathobiology, Faculty of Veterinary Medicine, Razi University, Kermanshah, Islamic Republic of Iran
- 4Department of Psychology, University of Evansville, Evansville, IN 47722, USA
Corresponding Author
Isaac Karimi; Department of Biology, Faculty of Science, Razi University, Kermanshah, Iran. E-mail: isaac_karimi2000@yahoo.com / karimiisaac@razi.ac.ir
Citation
Isaac Karimi, et al. Nootropic Effects of Quince Leaf (Cydonia Oblonga Miller.) Decoct in Mice: A Neurobehavioral Approach Complemented With Kinetics and Molecular Docking Studies of Encephalic Acetyl Cholinesterase Inhibition (2017) Bioinfo Proteom Img Anal 3(2): 196- 202.
Copy rights
© 2017 Isaac Karimi. This is an Open access article distributed under the terms of Creative Commons Attribution 4.0 International License.
Keywords
Abstract
Cydonia oblonga Miller (Quince) is an herbal medicine that is reported to prevent amnesia in Kurdish ethnomedicine. The aim of this study was to evaluate nootropic effects of quince leaf decoction (QLD). Forty mice subdivided into four equal groups i.e., control group was gavaged daily with distilled water while other three groups were gavaged with 0.92, 1.85, and 3.70 g/dl of fresh QLD for 28 days. Behavioral toxicology, encephalic acetylcholinesterase (AChE) activity and molecular docking of quince phyto-compounds against AChE were measured. The anxiety, exploration and learning and spatial memory were not altered after intake of QLD in mice. The encephalic AChE activity decreased hormetically in QLD-treated mice compared with control group, which connotes nootropic property of QLD. Based on the results of molecular docking of earlier reported phyto-chemicals of QLD, quercetin-3-O-galactoside and 3- and 5-caffeoylquinic acid showed considerable binding energies to AChE and may involve in AChE inhibitory effects of QLD in mice. QLD intake did not lead to behavioral toxicity and exerted AChE inhibition and would be rationalized as a putative phyto-nootropic remedy.
