Omega-3 Fatty Acids Improve Lipid Metabolism and Inflammatory Markers in Patients with Heart Failure Undergoing Exercise Training
Fernanda da Silva Casagrande, Vitor Giatte Angarten, Anderson Zampier Ulbrich, Raul Cavalcante Maranhao, Tales de Carvalho
Affiliation
1Post-Graduation Program in Nutrition of the Federal University of Santa Catarina, Florianopolis, Florianopolis-SC, Brazil
2Post-Graduation Program in Science of Human Movement of the State University of Santa Catarina, Florianopolis-SC, Brazil
3Lipid Metabolism Laboratory, Heart Institute (InCor) of the University of São Paulo Medical School, Sao Paulo-SP, Brazil
4Department of Clinical Analyses, Federal University of Santa Catarina, Florianopolis- SC, Brazil
Corresponding Author
Edson Luiz da Silva, Department of Clinical Analysis, Health Sciences Center, Federal University of Santa Catarina, Campus, s/n, Trinity, 88.040-370, Florianópolis, SC, Brazil. Telephone: +55-48-3721-97.12; Fax: +55-48-3721-5072; E-mail:edson.silva@ufsc.br; dasilvael@hotmail.com
Citation
da Silva, E. L. et al. Omega-3 Fatty Acids Improve Lipid Metabolism and Inflammatory Markers in Patients with Heart Failure Undergoing Exercise Training. (2015) J Food Nutr Sci 2(1): 70-75.
Copy rights
© 2015 da Silva, E. L. This is an Open access article distributed under the terms of Creative Commons Attribution 4.0 International License.
Keywords
Abstract
We hypothesize whether omega-3 (n-3) polyunsaturated fatty acids (PUFA) supplementation may improve the lipid metabolism and inflammatory biomarkers in heart failure (HF) patients undergoing exercise training. Sixteen male patients, who were participating in a physical cardiac rehabilitation program, ingested 4.8 g of fish oil daily (2.51 g of eicosapentaenoic and docosahexaenoic acids) for 60 days. Blood samples were collected at baseline and after 60 days of n-3 PUFA supplementation for analysis. The paired Student t-test was applied to detect differences (p < 0.05). The n-3 PUFA significantly reduced the levels of triglyceride (28.9%), small dense LDL- cholesterol (16.2%), non-HDL-cholesterol (9.0%), and TNF-α (17.8%) after 60 days (p < 0.05). Furthermore, the transfer of cholesteryl-ester to HDL increased by 23.1% (p < 0.05). In summary, the n-3 PUFA supplementation improved the lipid metabolism and low-grade systemic inflammation in HF patients submitted to exercise training, which may lower the risk of cardiovascular events.
