Potential Effect of Meloxicam and Tramadol on Neuropathic Wound Healing in Rats

Affiliation

¹Department of Anesthesiology, Vetsuisse Faculty, University of Zurich, Switzerland

²Surgery, Anesthesiology and Radiology Department, Faculty of Veterinary Medicine, Mansoura University, Egypt

³Faculty of Science, Medical Physics Department, King Abdulaziz University, Kingdom of Saudi Arabia

Abstract

Introduction: Pain management in animals can be increased by inappropriate housing, handling, and restraint and by utilizing unsuitable experimental techniques especially when surgery including in the protocol. Proper surgical techniques can decreased complications which contribute to postoperative comfort.
Objective: The study assessed the potential effect of meloxicam and tramadol or their combination as multi analgesic model on neuropathic wound healing in rats.
Methods: Rats had randomly assigned into 4 groups (10 rats for each treatment). G1 that didn’t receive any treatment, G2 receive postoperative tramadol hydrochloride (15 mg/kg; Tramal 5%, Minpharm, Gru¨nenthal, Germany; T15), G3 received meloxicam, (6 mg/kg; Anti-CoxII0.5 %, Adwia, Cairo, Egypt; M6) and G4 receive both T15 and M6 that include post-operative T15, M6, T15 + M6 from the 5^th till 11^th days post-operative.
Results: Granulation tissue was less neovascularization of the analgesic treatments was seen on day 10 postoperatively than in Control group. At day 14 postoperative the rats treated with M 6 mg/kg and T 15 mg/kg + M 6 mg/kg had increased of mononuclear cells in comparison to the others. Granulation tissue showed less proliferation of fibroblast and collagen in the analgesic treatments. Epithelial regeneration and collagen deposition were more prominent in the T 15 mg/kg compared to other treatments. There was decreased in granulation tissue inflammatory exudates in all treated animals.
Conclusion: The present study indicated that meloxicam and their combination leads to a slight delaying in the process of wound healing.