Affiliation

• ¹University Hospital Arnau de Vilanova (University of Lleida), Surgery Unit, Endocrinology and Nutrition Department. Research unit in Diabetes and Metabolism, Research Institute of Valld’Hebron (UAB) and CIBERDEM (ISCIII).
• ²Department of Biochemistry, University Hospital Valld’Hebron, UAB, Spain
• ³Department of Biochemistry and Molecular Biomedicine, Faculty of Biology, University of Barcelona, Spain
• ^†Juan Antonio Baena-Fustegueras and Julia Peinado Onsurbe share senior authorship

Corresponding Author

Dr. Julia Peinado-Onsurbe, Department of Biochemistry and Molecular Biomedicine, Faculty of Biology, University of Barcelona, Av. Diagonal 643, 08028 Barcelona, Spain, Tel: +34-934021524/48; Fax: +34-934021559; E-mail: jpeinado@ub.edu

Citation

Baena-Fustegueras, J.A., et al. Rapid Perioperative Changes in the Quantitative Properties of Plasma Lipases and Lipoproteins in Morbidly Obese Surgical Patients. (2017) J diab Obes 4(2): 1- 11.

Copy rights

© 2017 Peinado-Onsurbe, J. This is an Open access article distributed under the terms of Creative Commons Attribution 4.0 International License.

Keywords

Abstract

Background: The impact of bariatric surgery on abnormalities in blood lipids and lipoprotein metabolism during the perioperative period has been poorly studied.
Objective: We studied the impact of bariatric surgery on the composition and quantitative properties of lipoproteins and the activity of lipases in the plasma of perioperative morbidly obese patients.
Methods: We examined the plasma lipoproteins and lipolytic activities of 34 morbidly obesepatients one month before surgery (OB), pre-anaesthesia (-S), post-anaesthesia (+S), and one day and one month after open Roux-en-Y gastric bypass (RYGB) surgery.
Results: Surgical injury induced acute stress, as evidenced by transitory hyperglycaemia and elevated plasma levels of stress hormones. Lipid profiles revealed a significant reduction during surgery and the day after in the plasma levels of total cholesterol (p < 0.0001), which was mainly due to a decrease in low-density lipoprotein cholesterol (cLDL) and was confirmed with a significant reduction in the plasma levels of LDL (approximately 26% reduction). Significant (p < 0.0001) changes were detected in the plasma levels of high-density lipoprotein cholesterol (cHDL) as well as a significant decrease (approximately 19% reduction) in the plasma levels of HDL. A significant (p < 0.0001) rise was noted in the plasma levels of both Lipoprotein Lipase (LPL) (approximately 2.6-fold increase) and hepatic lipase (HL) (approximately 2.2-fold increase) on the day after surgery, occurring simultaneously with the maximum increase in C-reactive protein (CRP) and a day after the peak values for non-esterified fatty acid (NEFA), adrenocorticotropin hormone (ACTH), cortisol and glucose.
Conclusion: The present study reveals unreported quantitative perioperative changes in plasma lipases and lipoproteins and related metabolic determinants that may contribute to the adaptive metabolic response to RYGB-induced stress.
Summary
  There was a significant rise in the plasma levels of plasma lipases on the day after surgery in morbidly obese patients, co-occurring with the maximum increase in C-reactive protein.
  Lipid profiles revealed a significant reduction during surgery and the day after in the plasma levels of cholesterol. Stress pre-/post-surgery caused important changes in NEFA, ketone bodies and other related parameters that could be used as markers of surgery risk.