Solitary Fibrous Tumour of the Pleura and Paraneoplastic Symptoms: A Case Report and Literature Review
Alexander Braathen1, Uffe Bodtger1,2,3*
Affiliation
- 1Institute for Regional Health Research, University of Southern Denmark; Odense, Denmark
- 2Department of Pulmonology, Naestved Hospital, Nastved, Denmark
- 3Department of Pulmonology, Zealand University Hospital Roskilde; Roskilde, Denmark
Corresponding Author
Dr. Uffe Bodtger, MD, PhD, Associate Research Professor, Department of Pulmonology, Naestved Hospital, 61, Ringstedgade, DK-4700 Naestved, Denmark, Tel: +45 5651 4592/ Fax: +45 5651 3772; E-mail: ubt@regionsjaelland.dk
Citation
Bodtger, U., et al. Solitary Fibrous Tumour of the Pleura and Paraneoplastic Symptoms: A Case Report and Literature Review. (2017) Int J Cancer Oncol 4(2): 1-5.
Copy rights
© 2017 Bodtger, U. This is an Open access article distributed under the terms of Creative Commons Attribution 4.0 International License.
Keywords
Abstract
Background: Solitary fibrous tumors of the pleura (SFTP) are rare neoplasms deriving from mesenchymal cells. They are mostly benign and may be accompanied by paraneoplastic syndromes, particularly hypoglycaemia and hypertrophic pulmonary osteoarthropathy (HPO).
Methods: A Case Report of a patient with HPO preceding respiratory symptoms secondary to a huge SFTP which was surgically removed and found benign. A literature search was conducted on PubMed using the MeSH terms: secondary hypertrophic osteoarthropathy, solitary fibrous tumor, and solitary fibrous tumor of the pleura. Searches were limited to abstract, full text and English language. Articles from 1946 to 2016 were browsed and relevant articles extracted and reviewed.
Results: Our case patient experienced only partial remission of HPO despite benign histology and no signs of recurrence 3 years after surgery. This is in contrast to the literature. This report reviews the various mechanisms suggested to be involved in development of HPO: the humoral, immunologic, and neurogenic theory.
Conclusion: SFTP has almost all characteristics for development of HPO but all these resolves after surgical resection. Recurrence of HPO is thus indicative of SFTP recurrence, which must be explored thoroughly.
