Stem Cells and Stem Cells / Precursors-Derived Extracellular Vesicles in Heart Failure: What is Better for Cardiac Regeneration?
Affiliation
Internal Medicine Department, State Medical University for Zaporozhye, 26, Mayakovsky Av, Zaporozhye, Postcode 69035, Ukraine
Corresponding Author
Alexander Berezin, Professor, MD, PhD, Consultant of Therapeutic Unit, Internal Medicine Department, State Medical University for Zaporozhye, 26, Mayakovsky Av, Zaporozhye, Postcode 69035, Ukraine, Tel: +38 061 2894585; Fax: +38 0612894585; E-mail: aeberezin@gmail.com
Citation
Berezin, A. Stem Cells and Stem Cells / Precursors-Derived Extracellular Vesicles in Heart Failure: What is better for Cardiac Regeneration? (2018) J Stem Cell Regen Biol 4(1): 1- 3.
Copy rights
© 2018 Berezin, A. This is an Open access article distributed under the terms of Creative Commons Attribution 4.0 International License.
Keywords
Abstract
Heart Failure (HF) is a major factor contributing to premature death in patients with established Cardiovascular (CV) disease. Current cell therapies of HF based on at least two different approaches, in which stem cell transplantation and Extracellular Vesicles (EV) received from pre-treated cells, were used. Although in HF restoring cardiac function aimed to improve survival is a target of cell therapy, it is not yet yielded whether isolated EVs from circulating progenitor cells, induced Pluripotent Stem Cells (iPSCs), human embryonic stem cells-derived CV progenitors (HESC-Pg) would be effective translators of reparative signals for cardiac repair. The editorial depicts the role of different cell strategies in HF. It has emphasized lack of strong evidence of clinical advantages implanted EVs to human cells to iPSCs in HF requires comparison in large clinical trials.
