Synthesis and characterization of Ursolic acid loaded poly (lactic-co-glycolic acid) nanoparticles and Caffiene loaded poly (lactic-co-glycolic acid) nanoparticles in colorectal cancer cell line
Jose Merlin, J.P1*, Venkadesh, B2, Sheeja S Rajan3
Affiliation
- 1PG & Research Department of Zoology, Muslim Arts College, Thiruvithancode, Tamilnadu, India
- 2PG & Research Department of Zoology, Government Nandanam Arts College Chennai, Tamilnadu, India
- 3Department of Biochemistry, Theivanai Ammal College for Women Villupuram, Tamilnadu, India
Corresponding Author
Jose Merlin, J.P, PG & Research Department of Zoology, Muslim Arts College Thiruvithancode - 629 174, Tamilnadu, India, Tel: +91 9442094520; E-mail: jose4bio87@gmail.com
Citation
Jose Merlin, J.P. Synthesis and Characterization of Ursolic Acid Loaded Poly (Lactic-Co-Glycolic Acid) Nanoparticles and Caffiene Loaded Poly (Lactic-Co-Glycolic Acid) Nanoparticles in Colorectal Cancer Cell Line. (2018) J Nanotechnol Material Sci 5(1):1- 7
Copy rights
© 2018 Jose Merlin, J.P This is an Open access article distributed under the terms of Creative Commons Attribution 4.0 International License.
Keywords
Abstract
The aim of the present study was to develop UA-PLGA NPs and Caf -PLGA NPs to study its anticancer efficacy in colorectal cells in vitro. The method used for the study was to synthesis the nanoparticles, Particle size, size distribution and zeta potential, Drug encapsulation efficiency and in vitro drug release. Then the nanoparticles were subjected in cancer cell lines and the parameters used were Drug treatment and dose fixation study, Apoptotic morphological changes. The results indicate that the chemo sensitization of drug loaded nanoparticles demonstrated increased anticancer property in cancer cells than UA-PLGA NPs and Caf - PLGA NPs treatment alone.
