Affiliation

• ¹Clinical Psychology, Olom Tahghighat University, Honorary Member of Young Researchers and Elite club, Tehran, Iran, Ambassador of European Association for Cancer Research (EACR), England, Nottingham
• ²Young Researchers and Elite club, Central Tehran Branch, Islamic Azad University, Tehran, Iran, Honorary Board Member of Weston A. Price Foundation (WAPF), Ambassador of European Association for Cancer Research (EACR), England, Nottingham

Corresponding Author

Somayeh Zaminpira, Ms.c. in Clinical Psychology, Olom Tahghighat University, Honorary Member of Young Researchers and Elite club, Tehran, Iran, Ambassador of European Association for Cancer Research (EACR), England, Nottingham, E-mail: Saina.monthly@gmail.com; banafsheh_pira@yahoo.com

Citation

Zaminpira, S., et al. The Impact of Serotonin on the Cause and Treatment of Cancer. (2018) Int J Cancer Oncol 5(1): 1- 7.

Copy rights

© 2018 Zaminpira, S. This is an Open access article distributed under the terms of Creative Commons Attribution 4.0 International License.

Keywords

Abstract

  This review article goes through many researches based on the effectiveness of the neurotransmitter serotonin on cancer cells and also the impact of SSRIs (selective serotonin reuptake inhibitors) drugs on the cause of certain types of cancers. Serotonin has been shown to be a mutagenic factor for a wide range of normal and tumor cells. Serotonin exhibits a growth stimulatory effect in aggressive cancers and carcinoids usually through 5- HT1 and 5-HT2 receptors. In contrast, low doses of serotonin can inhibit tumor growth via the decrease of blood supply to the tumor, suggesting that the role of serotonin on tumor growth is concentration-dependent. Serum serotonin level was found to be suitable for prognosis evaluation of urothelial carcinoma in the urinary bladder, adenocarcinoma of the prostate and renal cell carcinoma.The mechanism that connect serotonin with tumor evolution seem to be related to the serotonin impact on tumor associated macrophages.