Affiliation

• ¹The Institute of Oncology, Tehran University of Medical Sciences, Tehran
• ²Sacoor Medical Group, London, United Kingdom
• ³International Centre for genetic Engineering and biotechnology, Aruna Asaf Ali Marg, New Delhi, India
• ⁴Institute of liver and biliary sciences, sector D1 vasant kunj, New Delhi, India

Corresponding Author

Prof. George Zhu, The Institute of Oncology, Tehran University of Medical Sciences, Tehran, E-mail: sansan4240732@163.com

Citation

Zhu, G., et al. Treatment of Advanced Hepatocellular Carcinoma (HCC) with the Combined Protocol of Chemotherapy 5-Fluorouracil and Traditional Medicine: Report of Ten Cases. (2017) Clin Trials Pathol Case Stud 2(2): 61- 65.

Copy rights

© 2017 Zhu, G. This is an Open access article distributed under the terms of Creative Commons Attribution 4.0 International License.

Keywords

Abstract

Background: The global burden of Hepatocellular Carcinoma (HCC) is significant. In search for the effective approach of PHC, we had summarized the retrospective study of HCC under remission,with the combined protocol of chemotherapy and traditional medicine.
Methods: All ten patients with HCC were in progressive at hospitalization.The criteria of Complete Remission (CR) and/or Partial Remission (PR) is according to the rules where physician have in common with in clinics.
Results: Ten advanced hepatocellular carcinomas had been successfully treated using combination chemotherapy and traditional medicine. Six of ten HCCs (three patients with liver CT tumor 6.3 × 4.5, 11.1 × 6.2, 3.0 × 2.7 cm, respectively, one patient AFP 7500 ng/ml) obtained complete remission through 5-Flourouracil and traditional medicine. Two HCCs (one patient AFP 200ng/ml, ascites +++, icterus index 100 u) obtained complete remission through cantharidine and traditional medicine. The main protocol of traditional medicine with adjuvant the antibiotics regimen and small dosage of dexamethasone (prednisone) administration was given in a primary hepatocellular carcinoma (AFP +, ascites +++, Jaundice +++, liver tumor 3.2 × 3.0). One acute promyelocytic leukemia complicated with metastatic hepatocellular carcinoma (7.0 × 4.5 cm) was in CR with All-Trans Retinoic Acid (ATRA) and traditional medicine. All ten patients with disease-free survival were 2,2,8,6,10,15,20,20 years,18 months (died in HCC relapse), and 20 months (died in leukemia relapse) respectively.
Conclusion: In this paper we observed in detail the objective response of the combined protocol of chemotherapy (mainly 5-Fluorouracil) and traditional medicine in the treatment of Hepatocellular Carcinoma (HCC). Interesting,one case was only given All-Trans Retinoic Acid (ATRA) and traditional medicine. A Hepatitis B Virus (HBV) integration in a human steroid hap Retinoic Acid Receptor (RAR β) previously detected may involve in hepatocellular carcinogenesis, and ATRA use in this case. And also, an additional data indicate that human Hepatocyte Growth Factor (HGF) and HGF receptor (HGFR/metoncogenic receptor) act as a trigger for liver regeneration after partial hepatectomy and liver injury, even in (hepatocellular) carcinogenesis, which was also discussed.