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Short Communication
Publish Date : 2017-10-03
Journal of Medicinal Chemistry and Toxicology

Active Targeted Nanoparticles for Anti– Cancer Nano Drugs Delivery across the Blood– Brain Barrier for Human Brain Cancer Treatment, Multiple Sclerosis (MS) and Alzheimer's Diseases Using Chemical Modifications of Anti– Cancer Nano Drugs or Drug– Nanoparticles through Zika Virus (ZIKV) Nanocarriers under Synchrotron Radiation

Alireza Heidari
Alireza Heidari
Article information 

Affiliation

Faculty of Chemistry, California South University, 14731 Comet St. Irvine, CA 92604, USA

Corresponding Author

Alireza Heidari, Faculty of Chemistry, California South University (CSU), 14731 Comet St. Irvine, CA 92604, USA. E-mail: Scholar.Researcher.Scientist@gmail.com

Citation

Alireza Heidari. Active Targeted Nanoparticles for Anti–Cancer Nano Drugs Delivery across the Blood–Brain Barrier for Human Brain Cancer Treatment, Multiple Sclerosis (MS) and Alzheimer’s Diseases Using Chemical Modifications of Anti–Cancer Nano Drugs or Drug–Nanoparticles through Zika Virus (ZIKV) Nanocarriers under Synchrotron Radiation. (2017) J Med Chem Toxicol 2(2): 90-94.

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© 2017 Alireza Heidari. This is an Open access article distributed under the terms of Creative Commons Attribution 4.0 International License.

Introduction
 

  The demand for active targeted nanoparticles for anti–cancer Nano drugs delivery across the blood–brain barrier for human brain cancer treatment, Multiple Sclerosis (MS) and Alzheimer’s diseases using chemical modifications of anti–cancer Nano drugs or drug–nanoparticles through Zika Virus (ZIKV) nanocarriers under synchrotron radiation has been significantly increasing in the world market due to their increased applications for various end uses[1-42]. The high crystalline nature of active targeted nanoparticles for anti–cancer Nano drugs delivery across the blood–brain barrier for human brain cancer treatment, Multiple Sclerosis (MS) and Alzheimer’s diseases using chemical modifications of anti–cancer Nano drugs or drug–nanoparticles through Zika Virus (ZIKV) nanocarriers under synchrotron radiation and physically hydrophobic nature serves as barrier for easy processing. Active targeted nanoparticles for anti–cancer Nano drugs delivery across the blood–brain barrier for human brain cancer treatment, Multiple Sclerosis (MS) and Alzheimer’s diseases using chemical modifications of anti–cancer Nano drugs or drug–nanoparticles through Zika Virus (ZIKV) nanocarriers under synchrotron radiation is usually treated with caustic to make them hydrophilic but they lead to decrease in strength but lipase treatment limited only to surface of active targeted nanoparticles for anti–cancer Nano drugs delivery across the blood–brain barrier for human brain cancer treatment, Multiple Sclerosis (MS) and Alzheimer’s diseases using chemical modifications of anti–cancer Nano drugs or drug–nanoparticles through Zika Virus (ZIKV) nanocarriers under synchrotron radiation as the enzymes are bulky in nature they cannot penetrate into the polymeric chain of active targeted nanoparticles for anti–cancer Nano drugs delivery across the blood–brain barrier for human brain cancer treatment, Multiple Sclerosis (MS) and Alzheimer’s diseases using chemical modifications of anti–cancer Nano drugs or drug–nanoparticles through Zika Virus (ZIKV) nanocarriers under synchrotron radiation and their strength is not reduced. An attempt has been made to make the fiber hydrophilic in nature. This short communication gives the process of treating active targeted nanoparticles for anti–cancer Nano drugs delivery across the blood–brain barrier for human brain cancer treatment, Multiple Sclerosis (MS) and Alzheimer’s diseases using chemical modifications of anti–cancer Nano drugs or drug–nanoparticles through Zika Virus (ZIKV) nanocarriers under synchrotron radiation with ester cleaving enzyme lipase from bacterial species bacillus sp. As a result of lipase treatment, it is observed that their hydrophilic property is improved which is tested by capillary raise wicking test and drop dissipations test. The increase in the number of hydrophilic groups like –COOH and –OH due to the cleavage of polyethylene terephthalate ester may be the reason for improved hydrophilicity. The increase in presence of –COOH and –OH is confirmed by treatment of active targeted nanoparticles for anti–cancer Nano drugs delivery across the blood–brain barrier for human brain cancer treatment, Multiple Sclerosis (MS) and Alzheimer’s diseases using chemical modifications of anti–cancer Nano drugs or drug–nanoparticles through Zika Virus (ZIKV) nanocarriers under synchrotron radiation with basic dye and reactive remazol dyes, respectively. There is a reduction in pilling of active targeted nanoparticles for anti–cancer Nano drugs delivery across the blood–brain barrier for human brain cancer treatment, Multiple Sclerosis (MS) and Alzheimer’s diseases using chemical modifications of anti–cancer Nano drugs or drug–nanoparticles through Zika Virus (ZIKV) nanocarriers under synchrotron radiation after lipase treatment. It is founded that it may be an economical method of treatment for active targeted nanoparticles for anti–cancer Nano drugs delivery across the blood–brain barrier for human brain cancer treatment, Multiple Sclerosis (MS) and Alzheimer’s diseases using chemical modifications of anti–cancer Nano drugs or drug–nanoparticles through Zika Virus (ZIKV) nanocarriers under synchrotron radiation and its blends to improve the comfort properties.

  Active targeted nanoparticles for anti–cancer Nano drugs delivery across the blood–brain barrier for human brain cancer treatment, Multiple Sclerosis (MS) and Alzheimer’s diseases using chemical modifications of anti–cancer Nano drugs or drug–nanoparticles through Zika Virus (ZIKV) nanocarriers under synchrotron radiation is a novel immunosuppressant for using in auto-immuno diseases and transplantation. This synthetic analogue of myriocin reduces the number of blood lymphocytes by redirecting theme to the lymph node. Active targeted nanoparticles for anti–cancer Nano drugs delivery across the blood–brain barrier for human brain cancer treatment, Multiple Sclerosis (MS) and Alzheimer’s diseases using chemical modifications of anti–cancer Nano drugs or drug–nanoparticles through Zika Virus (ZIKV) nanocarriers under synchrotron radiation is the first Sphingosin–1–Phosphate (S1P) receptor modulator. In Multiple Sclerosis (MS) and Alzheimer’s diseases, lymphocytes that circulate in the central nervous system (e.g. the brain and spinal cord) attack myelin sheath that surrounds and protect nerve fibers (Axons). Active targeted nanoparticles for anti–cancer Nano drugs delivery across the blood–brain barrier for human brain cancer treatment, Multiple Sclerosis (MS) and Alzheimer’s diseases using chemical modifications of anti–cancer Nano drugs or drug–nanoparticles through Zika Virus (ZIKV) nanocarriers under synchrotron radiation inhibits lymphocytes (T, B cells) recirculating. Clinical results after using active targeted nanoparticles for anti–cancer Nano drugs delivery across the blood–brain barrier for human brain cancer treatment, Multiple Sclerosis (MS) and Alzheimer’s diseases using chemical modifications of anti–cancer Nano drugs or drug–nanoparticles through Zika Virus (ZIKV) nanocarriers under synchrotron radiation showed that fingolimode reduced the rate of relapses more than 75% and inflammatory diseases activity as measured by Magnetic Resonance Imaging (MRI) up to 85%. In this short communication, derivative of active targeted nanoparticles for anti–cancer Nano drugs delivery across the blood–brain barrier for human brain cancer treatment, Multiple Sclerosis (MS) and Alzheimer’s diseases using chemical modifications of anti–cancer Nano drugs or drug–nanoparticles through Zika Virus (ZIKV) nanocarriers under synchrotron radiation such as H–d–Pro–FTY720, Boc–d– Pro–FTY720, H–d–Ala– FTY720, Boc–d–Ala–FTY72, for studies further pharmaceutical and neurological effect, were synthesized[43-50].

  Over the past decade, there has been an increasing interest in using active targeted nanoparticles for anti–cancer Nano drugs delivery across the blood–brain barrier for human brain cancer treatment, Multiple Sclerosis (MS) and Alzheimer’s diseases using chemical modifications of anti–cancer Nano drugs or drug–nanoparticles through Zika Virus (ZIKV) nanocarriers under synchrotron radiation for therapeutic goals in particular cancer therapy. The development of smart targeted nanoparticles (NPs) that can direct anti–cancer Nano drugs at a sustained rate to human cancer stem cells may cause better efficacy and lower toxicity for treating primary and advanced metastatic tumors. Furthermore, over the past decade, a wide variety of antibody–based targeting nanomolecules have been assessed for their potential application in cancer therapy. A novel class of nanomolecules, referred to as nucleic acid ligands (aptamers), has been developed that may rival antibodies in its potential for therapeutic and diagnostic applications. Aptamers are DNA or RNA oligonucleotides or modified DNA or RNA oligonucleotides that fold by intramolecular interaction into unique conformations with ligand–binding characteristics. Alireza Heidari and his co–workers at the BioSpectroscopy Core Research Laboratory at Faculty of Chemistry, California South University (CSU), Irvine, California, USA reported the synthesis and characterization of untrafine particles of some selected anti–cancer Nano drugs by sonochemical method via controlling the synthesized condition, reaction temperature and surfactant concentration were found to be central factor in controlling production morphology and no fundamental bonding change in the anti–cancer nanomolecules after preparation[51-73].

 
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